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AZD-6738

Chemical Structure AZD-6738

CAS No.: 1352226-88-0

AZD-6738 (AZD6738;AZD 6738;Ceralasertib)

Catalog No.: PC-45607Not For Human Use, Lab Use Only.

AZD-6738 (AZD6738, Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM.

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10 mg $120 In stock
50 mg $352 In stock
100 mg $592 In stock
500 mg Get quote
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD-6738 (AZD6738, Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM; shows no significant activity for ATM, DNA-PK and mTOR; inhibits ATR kinase-dependent CHK1 phosphorylation in cells (IC50=74 nM); enhances the therapeutic efficacy of cisplatin in xenograft models; orally active and bioavailable.

Gastric Cancer

Phase 2 Clinical

Physicochemical Properties

M.Wt 412.5085
Formula C20H24N6O2S
CAS No. 1352226-88-0
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 1 Month
Shipping
Solubility

DMSO: ≥ 38 mg/mL

Chemical Name

1H-Pyrrolo[2,3-b]pyridine, 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-

Clinical Information

References

1. Vendetti FP, et al. Oncotarget. 2015 Dec 29;6(42):44289-305.

2. Kwok M, et al. Blood. 2016 Feb 4;127(5):582-95.

3. Min A, et al. Mol Cancer Ther. 2017 Apr;16(4):566-577.

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