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AZD0011-PL

Chemical Structure : AZD0011-PL

CAS No.: 2374807-39-1

AZD0011-PL (AZD 0011-PL)

Catalog No.: PC-20188Not For Human Use, Lab Use Only.

AZD0011-PL is a highly potent Arginase (ARG) inhibitor with IC50 of 7/15 nM for ARG1/2, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AZD0011-PL is a highly potent Arginase (ARG) inhibitor with IC50 of 7/15 nM for ARG1/2, respectively.
AZD0011-PL only inhibits extracellular ARG available in TME or periphery, fully restores T cell proliferation.
AZD0011-PL is the bioactive form of AZD0011.

Physicochemical Properties

M.Wt 230.07
Formula C9H19BN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,4R)-4-amino-2-(4-boronobutyl)pyrrolidine-2-carboxylic acid

References

1. Doshi AS, et al. Mol Cancer Ther. 2023 Mar 13:MCT-22-0431.

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