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Chemical Structure : AZD 1678
Catalog No.: PC-61688Not For Human Use, Lab Use Only.
AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4.
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AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4.
CCR4 shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM).
CCR4 inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8.
| M.Wt | 352.1614 | |
| Formula | C11H8Cl2FN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kindon N, et al. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986.
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