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Chemical Structure : AZD 2066
Catalog No.: PC-60791Not For Human Use, Lab Use Only.
A potent, selective, highly CNS-penetrant mGluR5 antagonist.
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A potent, selective, highly CNS-penetrant mGluR5 antagonist; inhibits transient lower oesophageal sphincter relaxations (TLESRs) in animals and acid reflux, shows potential for treatment of gastro-oesophageal reflux.
Pain
Phase 1 Discontinued
| M.Wt | 381.82 | |
| Formula | C19H16ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rohof WO, et al. Aliment Pharmacol Ther. 2012 May;35(10):1231-42.
2. Nordmark A, et al. Eur J Clin Pharmacol. 2014 Feb;70(2):167-78.
3. Swedberg MD, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):212-22.
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