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Chemical Structure : AZD3778
Catalog No.: PC-20729Not For Human Use, Lab Use Only.
AZD3778 (AZD-3778) is a dual CCR3 and H1-receptor antagonistwith Ki of 54 nM for guinea-pig H1-receptor, inhibits binding of CR3 radioligand 125I-eotaxin to human CCR3-receptor expressed on CHO-cells with IC50 of 8 nM.
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AZD3778 (AZD-3778) is a dual CCR3 and H1-receptor antagonistwith Ki of 54 nM for guinea-pig H1-receptor, inhibits binding of CR3 radioligand 125I-eotaxin to human CCR3-receptor expressed on CHO-cells with IC50 of 8 nM.
AZD3778 inhibits chemotaxis of eosinophils.
AZD3778 also inhibits the binding of a specific H1-radioligand, 3H-pyrilamin, to the human H1-receptor expressed on CHO-cells with an IC50 of 40 nM.
AZD3778 inhibits histamine-induced calcium flux with an IC50 of 63 nM in human HeLa-cells expressing the human H1-receptor.
AZD3778 affects allergic inflammation and symptoms in allergic rhinitis.
| M.Wt | 526.47 | |
| Formula | C24H29Cl2N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lennart Greiff , et al. Respir Res. 2010 Feb 9;11(1):17.
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