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Chemical Structure : AZD4625
Catalog No.: PC-38549Not For Human Use, Lab Use Only.
AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM.
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AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM.
AZD4625 is a clinical development candidate for the treatment of KRASG12C positive tumors.
| M.Wt | 486.904 | |
| Formula | C24H21ClF2N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jason G. Kettle, et al. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.2c00369
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