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Chemical Structure : AZD4831
Catalog No.: PC-49289Not For Human Use, Lab Use Only.
AZD4831 (Mitiperstat, AZD-4831) is a potent, selective and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 1.5 nM, >450-fold vs thyroid peroxidase in vitro.
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AZD4831 (Mitiperstat, AZD-4831) is a potent, selective and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 1.5 nM, >450-fold vs thyroid peroxidase in vitro.
AZD4831 displayed moderate clearance and high oral bioavailability in rats.
AZD4831 AZD4831 dose dependently inhibited the peroxidase activity in lavage fluid in BALB/c mice with zymosan-induced neutrophilic peritonitis.
| M.Wt | 334.822 | |
| Formula | C15H15ClN4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tord Inghardt, et al. J Med Chem. 2022 Aug 25. doi: 10.1021/acs.jmedchem.1c02141.
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