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Chemical Structure : AZD 5597
Catalog No.: PC-61143Not For Human Use, Lab Use Only.
A highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2.
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A highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2; exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM, demonstrates anticancer activity in SW620 tumour xenograft, possesses suitable physiochemical and pharmacokinetic profiles for intravenous (i.v.) dosing.
| M.Wt | 437.513 | |
| Formula | C23H28FN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jones CD, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73.
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