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Chemical Structure : AZD7648
CAS No.: 2230820-11-6
Catalog No.: PC-73106Not For Human Use, Lab Use Only.
AZD7648 (AZD-7648) is a potent, selective inhibitor of DNA-PK catalytic subunit (DNA-PKcs) with IC50 of 0.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 500 mg | $1280 | In stock | |
| 1 g | Get quote |
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AZD7648 (AZD-7648) is a potent, selective inhibitor of DNA-PK catalytic subunit (DNA-PKcs) with IC50 of 0.6 nM.
AZD7648 displays no significant off-target activity in the protein kinome and only weak activity versus PI3Kα/γ lipid kinases.
AZD7648 increases genomic instability, resulting in cell growth inhibition and apoptosis in combination with the PARP inhibitor olaparib.
AZD7648 enhanced olaparib efficacy across a range of doses and schedules in xenograft and PDX models.
AZD7648 sensitizes tumor cells to radiotherapy and induces type I IFN-dependent durable tumor control in MC38, CT26, and B16-F10 models
| M.Wt | 380.412 | |
| Formula | C18H20N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one |
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1. Goldberg FW, et al. J Med Chem. 2020 Apr 9;63(7):3461-3471.
2. Nakamura K, et al. Clin Cancer Res. 2021 Aug 1;27(15):4353-4366.
3. Fok JHL, et al. Nat Commun. 2019 Nov 7;10(1):5065.
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