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Chemical Structure : AZD8529
CAS No.: 1092453-15-0
Catalog No.: PC-63180Not For Human Use, Lab Use Only.
AZD8529 (AZD-8529) is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes.
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AZD8529 (AZD-8529) is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes.
AZD8529 potentiates agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus and striatum.
AZD8529 decreases nicotine self-administration at doses (0.3-3 mg/kg) in monkeys, also reduces nicotine priming- and cue-induced reinstatement of nicotine seeking, decreases nicotine-induced accumbens dopamine release in rats.
| M.Wt | 487.483 | |
| Formula | C24H24F3N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,3-Dihydro-7-methyl-5-[3-(1-piperazinylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindol-1-one |
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1. Justinova Z, et al. Biol Psychiatry. 2015 Oct 1;78(7):452-62.
2. Caprioli D, et al. Biol Psychiatry. 2015 Oct 1;78(7):463-73.
3. Li X, et al. Psychopharmacology (Berl). 2016 May;233(10):1801-14.
4. Augier E, et al. Neuropsychopharmacology. 2016 Nov;41(12):2932-2940.
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