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Chemical Structure : AZD8848
Catalog No.: PC-20229Not For Human Use, Lab Use Only.
AZD8848 (AZD 8848) is a potent, selective TLR7 agonist with EC50 of 4 nM for induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for inhibition of IL-5.
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AZD8848 (AZD 8848) is a potent, selective TLR7 agonist with EC50 of 4 nM for induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for inhibition of IL-5.
AZD8848 has no activity against human TLR8 or against any of the other human TLRs.
AZD8848 is efficacious at reducing OVA-induced inflammation in the lung in the Brown Norway rat model.
| M.Wt | 569.71 | |
| Formula | C29H43N7O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Greiff L, et al. Respir Res. 2012 Jun 22;13(1):53.
2. Delaney S, et al. BMJ Open Respir Res. 2016 Feb 23;3(1):e000113.
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