Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AZD 9272
Catalog No.: PC-60792Not For Human Use, Lab Use Only.
A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM; does not elicit any agonist, antagonist or positive allosteric modulator on any of the other seven mGluR subtypes at 30 uM; completely reverses the glutamate-stimulated phosphatidyl inositol hydrolysis in human mGluR5-GHEK cells with IC50 of 26 nM, causes psychoactive effects selectively mediated by mGluR5 mechanisms in vivo,
Pain
Phase 1 Discontinued
| M.Wt | 284.226 | |
| Formula | C14H6F2N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Raboisson P, et al. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6974-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
