Abatacept | Human CTLA-4 Fc-Fusion Protein, T-cell costimulation modulator

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Chemical Structure : Abatacept

CAS No.: 332348-12-6

Abatacept (CTLA4lg, BMS-188667)

Catalog No.: PC-28462Not For Human Use, Lab Use Only.

Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extracellular domain of human CTLA4 linked to the Fc portion of IgG1 (hinge and CH2 and 3 domains), is a selective costimulation modulator that inhibits T cell activation by competing with CD28 for CD80 and CD86 binding.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	84.4 kDa
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. Linsley PS, et al. Science. 1992 Aug 7;257(5071):792-5.

2. Lenschow DJ, et al. Science. 1992 Aug 7;257(5071):789-92.

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Abatacept (CTLA4lg, BMS-188667)

Biological Activity

Physicochemical Properties

References

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