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Chemical Structure : Abiraterone
CAS No.: 154229-19-3
Catalog No.: PC-45937Not For Human Use, Lab Use Only.
A potent and irreversible CYP17A1 inhibitor with IC50 of 4 nM for 17α-hydroxylase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $49.6 | In stock | |
| 100 mg | $64 | In stock | |
| 200 mg | $80 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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A potent and irreversible CYP17A1 inhibitor with IC50 of 4 nM for 17α-hydroxylase; 6-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase; also acts as a partial antagonist of the AR, and as an inhibitor of the 3β-HSD, CYP11B1, and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4); is highly active in the treatment of castration-resistant prostate cancer; the active agent of prodrug abiraterone acetate.
Prostate Cancer
Preclinical
| M.Wt | 349.509 | |
| Formula | C24H31NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 1 mg/mL; H2O: < 1 mg/mL |
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| Chemical Name/SMILES |
Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3.beta.)- |
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1. Jarman M, et al. J Med Chem. 1998 Dec 31;41(27):5375-81.
2. O'Donnell A, et al. Br J Cancer. 2004 Jun 14;90(12):2317-25.
3. Attard G, et al. J Clin Oncol. 2009 Aug 10;27(23):3742-8.
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