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Chemical Structure : Abn-CBD
Catalog No.: PC-35025Not For Human Use, Lab Use Only.
Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM).
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Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM).
Abn-CBD is also a full agonist at GPR18, with EC50 of 0.835 uM for inducing p44/42 MAPK phosphorylation in HEK293 cells stably transfected with GPR18.
Abn-CBD regulates the migratory activity of murine BV-2 microglial cells with EC50 of 0.6 uM.
Abn-CBD induces endothelium-dependent vasodilation via a CB1/CB2/NO-independent mechanism and inhibits vasoconstriction induced by ET-1 in retinal arterioles.
Abn-CBD also is a nonretinoid inhibitor of cellular retinol-binding protein 1 (CRBP1) with Ki of 67 nM.
| M.Wt | 314.469 | |
| Formula | C21H30O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ryberg E, et al. Br J Pharmacol. 2007 Dec;152(7):1092-101.
2. Walter L, et al. J Neurosci. 2003 Feb 15;23(4):1398-405.
3. Alexander SP. Br J Pharmacol. 2012 Apr;165(8):2411-3.
4. Járai Z, et al. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14136-41.
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