Ac-LESD-CMK is a potent, selective inhibitor of caspase-8 with IC50 of 50 nM, inhibits homolog caspase-10 with IC50 of 520 nM.
Ac-LESD-CMK also is an efficient inhibitor of caspase-5 with IC50 of 2 uM.
Ac-LESD-CMK weakly inhibits the executioner caspases.
Ac-LESD-CMK inhibits the extrinsic apoptotic initiator caspases over 100 fold more potently than Ac-FLTD-CMK。
Ac-LESD-CMK inhibits caspase-1 with IC50 of 3.36 uM.
Ac-LESD-CMK efficiently blocks caspase-5 activity (IC50 = 2 μM) better than Ac-FLTD-CMK (IC50 = 15 μM).
Ac-LESD-CMK weakly inhibits mouse caspase-11 and the executioner caspases-3, -6, and -7.
Ac-LESD-CMK strongly inhibits activation of caspase-8-dependent cell death and modestly inhibits cell death triggered by inflammasome activation.
