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Chemical Structure : Acalisib
CAS No.: 870281-34-8
Catalog No.: PC-43131Not For Human Use, Lab Use Only.
Acalisib (GS-9820, CAL-120) is a potent, isoform-selective PI3K p110δ with IC50 of 12.7 nM, displays >100-fold selectivity over P110α/β/γ, and other class II/III PI3Ks, DNA-PK, mTOR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
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Acalisib (GS-9820, CAL-120) is a potent, isoform-selective PI3K p110δ with IC50 of 12.7 nM, displays >100-fold selectivity over P110α/β/γ, and other class II/III PI3Ks, DNA-PK, mTOR.
Acalisib (GS-9820, CAL-120) inhibits anti-FCϵRI PI3Kδ induced CD63 expression with IC50 of 14 nM in human whole blood with IC50 of 14 nM.
Acalisib (GS-9820, CAL-120) induces osteoclast retraction in rat osteoclasts, disrupts actin belts and blocks RANKL-stimulated osteoclast survival.
| M.Wt | 401.3965 | |
| Formula | C21H16FN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
4(3H)-Quinazolinone, 6-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]- |
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1. Shugg RP, et al. J Biol Chem. 2013 Dec 6;288(49):35346-57.
2. Lopez-Guadamillas E, et al. Aging (Albany NY). 2016 Nov 4;8(11):2747-2753.
3. Kater AP, et al. Blood Cancer J. 2018 Feb 12;8(2):16.
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