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Chemical Structure : Ack1 inhibitor 37
Catalog No.: PC-35147Not For Human Use, Lab Use Only.
Ack1 inhibitor 37 is a potent and selective Ack1 (TNK2) inhibitor with Ki of 0.3 nM, displays high selectivity over related kinases LCK, JAK3, KDR and TIE2 (Ki= 138, 6.5, 380 and 200 nM).
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Ack1 inhibitor 37 is a potent and selective Ack1 (TNK2) inhibitor with Ki of 0.3 nM, displays high selectivity over related kinases LCK, JAK3, KDR and TIE2 (Ki= 138, 6.5, 380 and 200 nM).
Ack1 inhibitor 37 demonstrates cell IC50 of 10 nM in cellular autophosphorylation assays, displays excellent ACK1 cellular inhibition, good kinase selectivity, and a suitable in vitro metabolic profile.
| M.Wt | 517.71 | |
| Formula | C28H31N5OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jiao X, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6212-7.
2. Mahajan K, et al. Cancer Lett. 2013 Sep 28;338(2):185-92.
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