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Chemical Structure : Acumapimod
CAS No.: 836683-15-9
Catalog No.: PC-45059Not For Human Use, Lab Use Only.
An orally active, potent p38 MAPK inhibitor that potently inhibits ex vivo LPS‐induced TNFα secretion with an IC50 of 44 ng/mL (115 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 25 mg | $200 | In stock | |
| 50 mg | $352 | In stock | |
| 100 mg | $592 | In stock |
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An orally active, potent p38 MAPK inhibitor that potently inhibits ex vivo LPS‐induced TNFα secretion with an IC50 of 44 ng/mL (115 nM); inhibits LPS‐stimulated TNFα release in the human whole blood assay with IC50 of 24 nM; shows antiinflammatory activity for treatment of acute as opposed to chronic inflammation disorders.
COPD
Phase 1 Clinical
| M.Wt | 385.4185 | |
| Formula | C22H19N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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| Chemical Name/SMILES |
Benzamide, 3-[5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl]-N-cyclopropyl-4-methyl- |
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1. De Buck S, et al. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700.
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