Aderbasb (INCB7839) | ADAM10/ADAM17 inhibitor

Chemical Structure : Aderbasib

CAS No.: 791828-58-5

Aderbasib (INCB007839, INCB7839)

Catalog No.: PC-25876Not For Human Use, Lab Use Only.

Aderbasb (INCB7839) is a potent, selective inhibitor of ADAM10 and ADAM17, inhibits EGFR ligand shedding from tumor cells, exhibits robust antineoplastic activity.

Packing	Price	Stock
5 mg	$248	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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Biological Activity

Aderbasb (INCB7839) is a potent, selective inhibitor of ADAM10 and ADAM17, inhibits EGFR ligand shedding from tumor cells, exhibits robust antineoplastic activity.

Physicochemical Properties

M.Wt	416.48
Formula	C21H28N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(6S,7S)-Methyl 7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate

References

1. Lois Witters, et al. Cancer Res. 2008 Sep 1;68(17):7083-9.

2. Lu Yang, et al. J Exp Clin Cancer Res. 2022 Jun 2;41(1):184.

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Aderbasib (INCB007839, INCB7839)

Biological Activity

Physicochemical Properties

References

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