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Chemical Structure : Aficamten
CAS No.: 2364554-48-1
Catalog No.: PC-38077Not For Human Use, Lab Use Only.
Aficamten (CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $398 | In stock | |
| 50 mg | $858 | In stock | |
| 100 mg | $1380 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Aficamten (CK-274) is a novel next-generation cardiac myosin inhibitor (IC50 =1.4 uM) for treatment of hypertrophic cardiomyopathy.
Aficamten (CK-274) provides a projected human half-life appropriate for once a day dosing, reaching steady state within two weeks, has no substantial CYP induction or inhibition in preclinical assessment and demonstrates a wide therapeutic window in vivo with a clear PK/PD relationship.
| M.Wt | 337.38 | |
| Formula | C18H19N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl- |
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1. Chuang C, et al. J Med Chem. 2021 Oct 14;64(19):14142-14152.
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