AgrC inhibitor CP-20t

Chemical Structure : AgrC inhibitor CP-20t

Catalog No.: PC-28772Not For Human Use, Lab Use Only.

CP-20t is a potent, small molecule inhibitor of Staphylococcus aureus agr quorum sensing (QS) system with IC50 of 9.8 nM (agr group-I), acts on AgrC and blocks hemolysis of rabbit red blood cells by group-I S. aureus with IC50 of 18 nM.

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Biological Activity

CP-20t is a potent, small molecule inhibitor of Staphylococcus aureus agr quorum sensing (QS) system with IC50 of 9.8 nM (agr group-I), acts on AgrC and blocks hemolysis of rabbit red blood cells by group-I S. aureus with IC50 of 18 nM.

Physicochemical Properties

M.Wt	440.58
Formula	C22H24N4O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(tert-butyl)phenyl)-2-(thiophene-3-carboxamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxamide

References

1. A P Clay, et al. ACS Chem Biol. 2026 Nov 3:10.1021/acschembio.6c00735.

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