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Albaconazole

Chemical Structure : Albaconazole

CAS No.: 187949-02-6

Albaconazole (UR-9825, UR9825)

Catalog No.: PC-22140Not For Human Use, Lab Use Only.

Albaconazole (UR-9825) is a broad-spectrum triazole antifungal agent with MIC of 30 nM against protozoan parasite Trypanosoma (Schizotrypanum) cruzi.

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Biological Activity

Albaconazole (UR-9825) is a broad-spectrum triazole antifungal agent with MIC of 30 nM against protozoan parasite Trypanosoma (Schizotrypanum) cruzi.
Albaconazole (UR-9825) is more potent against Candida spp. than both fluconazole and itraconazole.
Albaconazole (UR-9825) has good pharmacokinetic profile and excellent bioavailability.
Albaconazole (UR-9825) shows high in-vitro activity and efficacy in models of systemic candidosis in rats and rabbits, comparing favourably with fluconazole.

Physicochemical Properties

M.Wt 431.83
Formula C20H16ClF2N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-Chloro-3-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)quinazolin-4(3H)-one

References

1. Capilla J, et al. Antimicrob Agents Chemother. 2003 Jun;47(6):1948-51.

2. Urbina JA, et al. Antimicrob Agents Chemother. 2000 Sep;44(9):2498-502.

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