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Chemical Structure : Alisertib
CAS No.: 1028486-01-2
Catalog No.: PC-42757Not For Human Use, Lab Use Only.
Alisertib (MLN8237) is a potent and highly selective inhibitor of Aurora A (AURKA) with IC50 of 1.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $58 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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Alisertib (MLN8237) is a potent and highly selective inhibitor of Aurora A (AURKA) with IC50 of 1.2 nM.
Alisertib (MLN8237) has less activity against Aurora B (IC50=396.5 nM) and a 205-kinase panel.
Alisertib (MLN8237) inhibits proliferation of human tumor cell lines in vitro and produces tumor growth inhibition in solid tumor xenograft models.
| M.Wt | 518.9235 | |
| Formula | C27H20ClFN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 9.33 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy- |
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1. Manfredi MG, et al. Clin Cancer Res. 2011 Dec 15;17(24):7614-24.
2. Wen Q, et al. Cell. 2012 Aug 3;150(3):575-89.
3. Zhou N, et al. Clin Cancer Res. 2013 Apr 1;19(7):1717-28.
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