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Aloe-emodin

Chemical Structure : Aloe-emodin

CAS No.: 481-72-1

Aloe-emodin (Aloe emodin, Rhabarberone)

Catalog No.: PC-27954Not For Human Use, Lab Use Only.

Aloe-emodin (Aloe emodin, Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities, binds and inhibits mTORC2, inhibits both proliferation and anchorage-independent growth of PC3 cells, also inhibits HER-2 expression through the downregulation of Y-box binding protein-1 (YB-1), inhibits cancer metastasis and cancer stem cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Aloe-emodin (Aloe emodin, Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities, binds and inhibits mTORC2, inhibits both proliferation and anchorage-independent growth of PC3 cells, also inhibits HER-2 expression through the downregulation of Y-box binding protein-1 (YB-1), inhibits cancer metastasis and cancer stem cells.

Physicochemical Properties

M.Wt 270.24
Formula C15H10O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,8-Dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione

References

1. Liu K, et al. Carcinogenesis. 2012 Jul;33(7):1406-11.

2. Shen F, et al. Eur J Pharmacol. 2020 Nov 5;886:173550.

3. Ma JW, et al. Oncotarget. 2016 Sep 13;7(37):58915-58930.

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