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Chemical Structure : Alvespimycin
CAS No.: 467214-20-6
Catalog No.: PC-42558Not For Human Use, Lab Use Only.
Alvespimycin (17-DMAG) is a potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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Alvespimycin (17-DMAG) is a potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.
Alvespimycin (17-DMAG) also shows comparable binding affinity for Grp94 with EC50 of 65 nM.
Alvespimycin (17-DMAG) inhibits the migration and the extracellular matrix-invasiveness of HUVEC in vitro, also inhibits FGF-2 and VEGF-induced HUVEC proliferation and induces apoptosis.
| M.Wt | 616.7455 | |
| Formula | C32H48N4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]- |
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1. Bull EE, et al. Clin Cancer Res. 2004 Dec 1;10(23):8077-84.
2. Kaur G, et al. Clin Cancer Res. 2004 Jul 15;10(14):4813-21.
3. Ge J, et al. J Med Chem. 2006 Jul 27;49(15):4606-15.
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