Chemical Structure : Alvespimycin
CAS No.:
467214-20-6
Alvespimycin
(17-DMAG, KOS-1022, NSC 707545)
Catalog No. : PC-42558Not For Human Use, Lab Use Only.
Alvespimycin (17-DMAG) is a potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4255801
Biological Activity
Alvespimycin (17-DMAG) is a potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.Grp94 with EC50 of 65 nM.
Physicochemical Properties
M.Wt
616.7455
Formula
C32H48N4O8
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-
References
1. Bull EE, et al. Clin Cancer Res
2. Kaur G, et al. Clin Cancer Res
3. Ge J, et al. J Med Chem
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