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Chemical Structure : Alvespimycin hydrochloride
CAS No.: 467214-21-7
Catalog No.: PC-42839Not For Human Use, Lab Use Only.
A potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $80 | In stock | |
| 100 mg | $200 | In stock | |
| 200 mg | $328 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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A potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62 nM; also show comparable binding affinity for Grp94 with EC50 of 65 nM; inhibits the migration and the extracellular matrix-invasiveness of HUVEC in vitro, also inhibits FGF-2 and VEGF-induced HUVEC proliferation and induces apoptosis.
Blood Cancer
Phase 1 Discontinued
| M.Wt | 653.2065 | |
| Formula | C32H49ClN4O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 50 mg/mL |
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| Chemical Name/SMILES |
Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-, hydrochloride (1:1) |
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1. Jez JM, et al. Jez JM,
2. Bull EE, et al. Clin Cancer Res. 2004 Dec 1;10(23):8077-84.
3. Kaur G, et al. Clin Cancer Res. 2004 Jul 15;10(14):4813-21.
4. Ge J, et al. J Med Chem. 2006 Jul 27;49(15):4606-15.
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