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Alvimopan monohydrate

Chemical Structure : Alvimopan monohydrate

CAS No.: 1383577-62-5

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Alvimopan monohydrate (ADL 8-2698 monohydrate, LY 246736 monohydrate)

Catalog No.: PC-45976Not For Human Use, Lab Use Only.

Alvimopan monohydrate (ADL 8-2698, LY 246736) is a selective peripherally acting μ-opioid (MOR) antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Alvimopan monohydrate (ADL 8-2698, LY 246736) is a selective peripherally acting μ-opioid (MOR) antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.
Alvimopan prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.

Physicochemical Properties

M.Wt 442.5479
Formula C25H34N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-, hydrate (1:1)

References

1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70.

2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40.

3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.

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