Catalog No.: PC-25873Not For Human Use, Lab Use Only.
Amentoflavone is a naturally occurring biflavonoid with anti-inflammatory and anti-tumor properties, an antiangiogenic bioactive molecule that binds VEGFs preventing the interaction and phosphorylation of VEGF receptor 1 and 2 (VEGFR-1,VEGFR-2).
Amentoflavone is a naturally occurring biflavonoid with anti-inflammatory and anti-tumor properties, an antiangiogenic bioactive molecule that binds VEGFs preventing the interaction and phosphorylation of VEGF receptor 1 and 2 (VEGFR-1,VEGFR-2). Amentoflavone significantly inhibited GLI-1-mediated CRC cell proliferation, induced G1 phase arrest, and downregulated Cyclin D1/CDK4 expression, by targeting the GLI-1/IL-6/STAT3 signaling axis. Amentoflavone inhibited endothelial cell migration and capillary-like tube formation induced by VEGF-A or placental growth factor 1 (PlGF-1) at low uM concentration. Amentoflavone inhibited VEGF-A-induced chorioallantoic membrane neovascularization as well as tumor growth and associated neovascularization, as assessed in orthotropic melanoma and xenograft colon carcinoma models.
