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Chemical Structure : Amiselimod hydrochloride
CAS No.: 942398-84-7
Catalog No.: PC-45066Not For Human Use, Lab Use Only.
Amiselimod (MT-1303) hydrochloride is a prodrug S1P1 receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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Amiselimod (MT-1303) hydrochloride is a prodrug S1P1 receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators.
Amiselimod shows potent selectivity for S1P1 and high selectivity for S1P5 receptors, with minimal agonist activity for S1P4 and no distinct agonist activity for S1P2 or S1P3 receptors and approximately five-fold weaker GIRK activation than fingolimod-P.
Amiselimod exhibits potent therapeutic efficacy with minimal cardiac effects.
| M.Wt | 413.9026 | |
| Formula | C19H31ClF3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
1,3-Propanediol, 2-amino-2-[2-[4-(heptyloxy)-3-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1) |
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1. Sugahara K, et al. Br J Pharmacol. 2017 Jan;174(1):15-27.
2. Kappos L, et al. Lancet Neurol. 2016 Oct;15(11):1148-59.
3. Harada T, et al. Br J Clin Pharmacol. 2017 May;83(5):1011-1027.
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