Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Amitifadine hydrochloride
CAS No.: 410074-74-7
Catalog No.: PC-45454Not For Human Use, Lab Use Only.
Amitifadine hydrochloride (DOV-21947 hydrochloride) is a triple monoamine reuptake inhibitor that inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in HEK 293 cells expressing the corresponding human recombinant transporters (IC50 values of 12, 23, and 96 nM, respectively).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Amitifadine hydrochloride (DOV-21947 hydrochloride) is a triple monoamine reuptake inhibitor that inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in HEK 293 cells expressing the corresponding human recombinant transporters (IC50 values of 12, 23, and 96 nM, respectively).
Amitifadine hydrochloride reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg.
| M.Wt | 264.5787 | |
| Formula | C11H12Cl3N | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-, hydrochloride (1:1), (1R,5S)- |
|
1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104.
2. Warnock KT, et al. Pharmacol Biochem Behav. 2012 Nov;103(1):111-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
