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Chemical Structure : Amodiaquine
CAS No.: 86-42-0
Catalog No.: PC-20771Not For Human Use, Lab Use Only.
Amodiaquine (Amodiaquin, AQ) is an antimalarial agent and nuclear receptor Nurr1 (NR4A2) agonist, specifically binds to Nurr1-LBD (ligand binding domain) with EC50 of 20 uM.
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Amodiaquine (Amodiaquin, AQ) is an antimalarial agent and nuclear receptor Nurr1 (NR4A2) agonist, specifically binds to Nurr1-LBD (ligand binding domain) with EC50 of 20 uM.
Amodiaquine suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake.
Amodiaquine exhibits neuroprotective effect in rat PC12 cells.
Amodiaquine also is a potent inhibitor of histamine N-methyltransferase protects mice from Propionibacterium acnes (P. acnes)-primed and lipopolysaccharide (LPS)-induced hepatitis.
| M.Wt | 355.87 | |
| Formula | C20H22ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((7-chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol |
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1. Chun-Hyung Kim, et al. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61.
2. Keita Kinoshita, et al. J Neuroimmunol. 2019 May 15;330:48-54.
3. Akira Yokoyama, et al. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84.
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