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Andrographolide

Chemical Structure : Andrographolide

CAS No.: 5508-58-7

Andrographolide (Andrographis)

Catalog No.: PC-28518Not For Human Use, Lab Use Only.

Andrographolide is a diterpene lactone isolated from Cymbopogon schoenanthus, inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation, exhibits broad-spectrum antiviral properties.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Andrographolide is a diterpene lactone isolated from Cymbopogon schoenanthus, inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation, exhibits broad-spectrum antiviral properties.

Physicochemical Properties

M.Wt 350.46
Formula C20H30O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-one

References

1. Zhai ZJ, et al. Br J Pharmacol. 2014 Feb;171(3):663-75.

2. Gupta S, et al. Arch Virol. 2017 Mar;162(3):611-623.

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