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Chemical Structure : Ansamitocin P-3
CAS No.: 66547-09-9
Catalog No.: PC-45742Not For Human Use, Lab Use Only.
A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 50 mg | $392 | In stock | |
| 100 mg | $520 | In stock |
Bulk size, bulk discount!
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A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation; inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice.
| M.Wt | 635.1448 | |
| Formula | C32H43ClN2O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)- |
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1. Ootsu K, et al. Cancer Res. 1980 May;40(5):1707-17.
2. Venghateri JB, et al. PLoS One. 2013 Oct 4;8(10):e75182.
3. Martin K, et al. Cancer Immunol Immunother. 2014 Sep;63(9):925-38.
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