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Chemical Structure : Apicidin
CAS No.: 183506-66-3
Catalog No.: PC-62466Not For Human Use, Lab Use Only.
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay.
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Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay.
Apicidin induces morphological changes, cell cycle arrest at G1 phase, and accumulation of hyperacetylated histone H4 in Hela cells, changes the expression of p21WAF1/Cip1 and gelsolin.
Apicidin upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions.
| M.Wt | 623.78 | |
| Formula | C34H49N5O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl] |
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1. Darkin-Rattray SJ, et al. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.
2. Han JW, et al. Cancer Res. 2000 Nov 1;60(21):6068-74.
3. Bang SY, et al. Stem Cells Dev. 2015 Feb 15;24(4):520-33.
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