Chemical Structure : Apilimod
Catalog No.: PC-60412Not For Human Use, Lab Use Only.
A potent IL-12/IL-23 inhibitor that down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines (IC50=2 nM).
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A potent IL-12/IL-23 inhibitor that down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines (IC50=2 nM); suppresses Th1 but not Th2 immune response in mice; binds to PIKfyve and blocks its phosphotransferase activity (IC50=14 nM), has no activity on PIP4K, PIP5K, mTOR, PI3K and PI4K isoforms; also potently blocks infections by EBOV and MARV in Huh 7, Vero E6 and primary human macrophage cells with IC50 of 10 nM.
Blood Cancer
Phase 2 Clinical
M.Wt | 418.49 | |
Formula | C23H26N6O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Wada Y, et al. Blood. 2007 Feb 1;109(3):1156-64.
2. Cai X, et al. Chem Biol. 2013 Jul 25;20(7):912-21.
3. Nelson EA, et al. PLoS Negl Trop Dis. 2017 Apr 12;11(4):e0005540.
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