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Chemical Structure : Aplaviroc
Catalog No.: PC-61968Not For Human Use, Lab Use Only.
Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.
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Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.
Aplaviroc blocks the calcium response effects of CCR5 activation by CCL5, and potently blocks in vitro the infection of R5-tropic HIV-1 (R5-HIV-1) at subnanomolar IC50.
| M.Wt | 577.722 | |
| Formula | C33H43N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Watson C, et al. Mol Pharmacol. 2005 Apr;67(4):1268-82.
2. Lalezari J, et al. AIDS. 2005 Sep 23;19(14):1443-8.
3. Adkison KK, et al. Antimicrob Agents Chemother. 2005 Jul;49(7):2802-6.
4. Nakata H, et al. Antimicrob Agents Chemother. 2008 Jun;52(6):2111-9.
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