Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Artepillin C
Catalog No.: PC-72794Not For Human Use, Lab Use Only.
Artepillin C (CREB-CRTC2 inhibitor APC) is an inhibitor of CREB/CRTC2 interaction (IC50=24.5 uM), dissociates the CREB/CRTC2 complex, directly binds to CREB with Kd of 3.2 uM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Artepillin C (CREB-CRTC2 inhibitor APC) is an inhibitor of CREB/CRTC2 interaction (IC50=24.5 uM), dissociates the CREB/CRTC2 complex, directly binds to CREB with Kd of 3.2 uM.
CREB-CRTC2 inhibitor APC inhibits CRTC2 interacting with CREB-ZIP and reduces acetyltransferase activity of CBP by binding with CREB protein directly.
Artepillin C attenuated gluconeogenesis in primary hepatocytes, reduced glucose output from primary hepatocytes induced by glucagon, remarkably decreased the mRNA accumulation of G6pc, Pck1, and Pgc-1α induced by glucagon in primary hepatocytes.|
Artepillin C could ameliorate hyperlipidemia in obese mice.
| M.Wt | 300.398 | |
| Formula | C19H24O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
|
|
1. Yaqiong Chen, et al. Nat Commun. 2022 Jan 11;13(1):246.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
