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Chemical Structure : Asivatrep
CAS No.: 1005168-10-4
Catalog No.: PC-43202Not For Human Use, Lab Use Only.
Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1.
Asivatrep inhibits capsaicin-evoked calcium influx in keratinocytes at sub-micromolar concentrations, blocks capsaicin-induced blood perfusion increase, and the accelerated barrier recovery from tape-stripping-induced barrier damages in hairless mice.
Asivatrep also attenuates dermatitis-associated barrier damages in Df and OXZ models.
| M.Wt | 491.4747 | |
| Formula | C21H22F5N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[(1R)-1-[3,5-difluoro-4-[(methylsulfonyl)amino]phenyl]ethyl]-3-[2-propyl-6-(trifluoromethyl)-3-pyridinyl]-, (2E)- |
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1. Yun JW, et al. J Dermatol Sci. 2011 Apr;62(1):8-15.
2. Yun JW, et al. J Invest Dermatol. 2011 Jul;131(7):1576-9.
3. Lim KM, et al. Arch Pharm Res. 2012 Mar;35(3):393-6.
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