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Atomoxetine hydrochloride

Chemical Structure : Atomoxetine hydrochloride

CAS No.: 82248-59-7

Atomoxetine hydrochloride (Tomoxetine;LY-139603)

Catalog No.: PC-45208Not For Human Use, Lab Use Only.

A selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM; shows weak affinity for 5-HT and dopamine transporters with IC50 of 77 and 1,451 nM, respectively; approved for the treatment of attention deficit hyperactivity disorder (ADHD).

Other Indication

Approved

Physicochemical Properties

M.Wt 291.8157
Formula C17H22ClNO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, hydrochloride (1:1), (γR)-

References

1. Bymaster FP, et al. Neuropsychopharmacology. 2002 Nov;27(5):699-711.

2. Sauer JM, et al. Clin Pharmacokinet. 2005;44(6):571-90.

3. Passamonti L, et al. Psychopharmacology (Berl). 2017 Aug;234(15):2289-2297.

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