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Chemical Structure : Atopaxar
CAS No.: 751475-53-3
Catalog No.: PC-61307Not For Human Use, Lab Use Only.
Atopaxar (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $268 | In stock | |
| 100 mg | $698 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Atopaxar (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.
Atopaxar (E5555) shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 of 64 nM and 31 nM, respectively, with no effect on platelet aggregation induced by either ADP or collagen.
Atopaxar (E5555) inhibits arterial thrombosis without affecting bleeding time in photochemically-induced thrombosis model guinea pigs.
| M.Wt | 527.6374 | |
| Formula | C29H38FN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(5,6-Diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone |
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1. Serebruany VL, et al. Thromb Haemost. 2009 Jul;102(1):111-9.
2. Angiolillo DJ, et al. Eur Heart J. 2010 Jan;31(1):17-28.
3. Kogushi M, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):131-7.
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