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Chemical Structure : Atopaxar hydrobromide
Catalog No.: PC-61308Not For Human Use, Lab Use Only.
Atopaxar hydrobromide (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.
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Atopaxar hydrobromide (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.
Atopaxar (E5555) shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 of 64 nM and 31 nM, respectively, with no effect on platelet aggregation induced by either ADP or collagen.
Atopaxar (E5555) inhibits arterial thrombosis without affecting bleeding time in photochemically-induced thrombosis model guinea pigs.
| M.Wt | 608.54 | |
| Formula | C29H38FN3O5.HBr | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Serebruany VL, et al. Thromb Haemost. 2009 Jul;102(1):111-9.
2. Angiolillo DJ, et al. Eur Heart J. 2010 Jan;31(1):17-28.
3. Kogushi M, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):131-7.
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