Catalog No.: PC-35046Not For Human Use, Lab Use Only.
Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I.
Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I.
Aumitin inhibits LC3 lipidation, and p62 degradation by starvation- as well as rapamycin-induced autophagy dose-dependently in MCF7-LC3 cells, suggesting inhibition of autophagic flux.
Aumitin inhibits mitochondrial respiration by targeting complex I with IC50 of 0.11 uM in HeLa cells.
Aumitin is a new tool compound for interrogating autophagy and mitochondrial respiration by means of complex I inhibition.
