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Aureobasidin A

Chemical Structure : Aureobasidin A

CAS No.: 127785-64-2

Aureobasidin A (AbA, LY295337, Basifungin)

Catalog No.: PC-73162Not For Human Use, Lab Use Only.

Aureobasidin A (AbA, Basifungin) is a cyclic depsipetide antifungal antibiotic, inhibits the inositolphosphorylceramide synthase AUR1.

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Biological Activity

Aureobasidin A (AbA, Basifungin) is a cyclic depsipetide antifungal antibiotic, inhibits the inositolphosphorylceramide synthase AUR1.
Aureobasidin A (AbA) arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides.
Aureobasidin A (AbA) is highly active in vitro against many pathogenic fungi, including Candida albicans, Cryptococcus neoformans, Blastomyces dermatitidis and Histoplasma capsulatum.
Aureobasidin A (AbA) is highly tolerated by mice and showed good efficacy in the treatment of murine systemic candidiasis when given orally or subcutaneously.

Physicochemical Properties

M.Wt 1101.42
Formula C60H92N8O11
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

References

1. Kino K, et al. FEBS Lett. 1996 Dec 9;399(1-2):29-32.

2. Hashida-Okado T, et al. Mol Gen Genet. 1996 May 23;251(2):236-44.

3. Takesako K, et al. J Antibiot (Tokyo). 1993 Sep;46(9):1414-20.

4. Heidler SA, et al. Antimicrob Agents Chemother. 1995 Dec;39(12):2765-9.

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