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Chemical Structure : Autogramin-1
CAS No.: 2375541-73-2
Catalog No.: PC-73084Not For Human Use, Lab Use Only.
Autogramin-1 is a potent autophagy inhibitor, inhibits autophagy induced by either starvation or mTORC1 inhibition with IC50 of 0.17 and 0.44 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $198 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Autogramin-1 is a potent autophagy inhibitor, inhibits autophagy induced by either starvation or mTORC1 inhibition with IC50 of 0.17 and 0.44 uM, respectively.
Autogramin-1 also inhibits LC3 lipidation and the degradation of p62, and selectively inhibits growth of glucose-starved MCF7 cells as compared to fed cells.
Autogramin-1 selectively targets cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A) and directly competes with cholesterol binding to the GRAMD1A StART domain.
GRAMD1A is required for autophagosome initiation.
| M.Wt | 485.559 | |
| Formula | C23H27N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
tert-butyl 2-(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazoline-7-carboxamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate |
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1. Laraia L, et al. Nat Chem Biol. 2019 Jul;15(7):710-720.
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