Chemical Structure : Autophagy activator AA-20
CAS No.:
351468-76-3
Autophagy activator AA-20
Catalog No.: PC-25244Not For Human Use, Lab Use Only.
Autophagy activator AA-20 is a promising small-molecule autophagy enhancer/ activator, enhances autophagy and lipid droplet clearance in human cells and in the nematode Caenorhabditis elegans.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Autophagy activator AA-20 is a promising small-molecule autophagy enhancer/ activator, enhances autophagy and lipid droplet clearance in human cells and in the nematode Caenorhabditis elegans.
AA-20 reduces polyglutamine aggregation in an autophagy-dependent manner in both human cells and C. elegans, where it also promotes fitness.
AA-20 extends lifespan in WT C. elegans, but not in autophagy-deficient mutants.
AA-20 acts, at least in part, through a mechanism involving the transcription factor EB, but without inhibiting the protein kinase mammalian target of rapamycin complex 1.
Physicochemical Properties
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M.Wt
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532.64
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Formula
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C26H24N6O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-[(6-ethoxybenzo[d]thiazol-2-yl)thio]-N2,N4-bis(4-methoxyphenyl)-1,3,5-triazine-2,4 diamine
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References
1. Tan EP, et al. Proc Natl Acad Sci U S A. 2025 Aug 12;122(32):e2423455122.
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