Chemical Structure : Autophagy inhibitor 5j
CAS No.:
Autophagy inhibitor 5j
Catalog No.: PC-25554Not For Human Use, Lab Use Only.
Autophagy inhibitor 5j is a potent late-stage autophagy inhibitor, trigger an ER stress response and interfere with cathepsin D maturation, potentially contributing to altered lysosomal trafficking.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Autophagy inhibitor 5j is a potent late-stage autophagy inhibitor, trigger an ER stress response and interfere with cathepsin D maturation, potentially contributing to altered lysosomal trafficking.
Autophagy inhibitor 5j induces strong accumulation of RFP-GFP-LC3 puncta as well as LC3-II, GABARAP-II and SQSTM1 protein levels, resembling the effects obtained with the well-known late-stage autophagy inhibitor Bafilomycin A1.
Autophagy inhibitor 5j (10 uM) inhibits the autophagic flux at a late-stage in RFP-GFP-LC3 HeLa cells and LNCaP cells.
Autophagy inhibitor 5j stimulates the cholesterol biosynthesis pathway, dysregulates lipid metabolism, and induces ER stress and accumulation of pro-cathepsin D。
Physicochemical Properties
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M.Wt
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390.50
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Formula
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C25H27FN2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(4-((dimethylamino)methyl)benzyl)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanamide
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References
1. Lallier M, et al. Autophagy Rep. 2025 Aug 7;4(1):2541597.
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