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Chemical Structure : Autophazole
Catalog No.: PC-72715Not For Human Use, Lab Use Only.
Autophazole is a novel autophagy inhibitor, promotes cancer cell death via caspase activation.
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Autophazole is a novel autophagy inhibitor, promotes cancer cell death via caspase activation.
Autophazole was internalized into lysosomes of cells where it induced lysosomal membrane permeabilization (LMP), promoted LMP-mediated apoptosis.
LMP induced by Autophazole caused release of cathepsins from lysosomes into the cytosol. Cathepsins in the cytosol cleaved Bid to generate tBid, which subsequently activated Bax to induce mitochondrial outer membrane permeabilization (MOMP).
Autophazole is a new chemical probe in efforts aimed at gaining a better understanding of the autophagic process.
| M.Wt | 659.831 | |
| Formula | C40H45N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sang-Hyun Park, et al. Chembiochem. 2021 Dec 10;22(24):3425-3430.
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