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Autoquin

Chemical Structure : Autoquin

CAS No.: 2424000-51-9

Autoquin

Catalog No.: PC-38229Not For Human Use, Lab Use Only.

Autoquin is a novel autophagy inhibitor (IC50=0.56 uM) by indirect modulation of the activity of the lysosomal enzymes acid sphingomyelinase and acid ceramidase.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Autoquin is a novel autophagy inhibitor (IC50=0.56 uM) by indirect modulation of the activity of the lysosomal enzymes acid sphingomyelinase and acid ceramidase.
Autoquin showed a dose‐dependent inhibition of EGFP‐LC3 puncta after 3 hours upon autophagy induction by amino acid starvation in the primary screening assay.
Autoquin is a lysosomotropic compound that acts as a functional inhibitor of acid sphingomyelinase, increases lysosomal mass and sequesters Fe2+ to the lysosomes in MCF7 cells, causing an increase in lysosomal reactive oxygen species.

Physicochemical Properties

M.Wt 418.512
Formula C26H27FN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S)-(2-(4-fluorophenyl)-6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methanol

References

1. Luca Laraia, et al. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5721-5729.

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