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Autotaxin-IN-13

Chemical Structure : Autotaxin-IN-13

CAS No.: 1588501-59-0

Autotaxin-IN-13 (ATX-i)

Catalog No.: PC-72882Not For Human Use, Lab Use Only.

Autotaxin-IN-13 ( ATX-i) is a highly potent, selective Autotaxin inhibitor with IC50 of 6 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Autotaxin-IN-13 ( ATX-i) is a highly potent, selective Autotaxin inhibitor with IC50 of 6 nM.
Autotaxin showed sufficient oral bioavailability and low plasma clearance in vivo as well as a suitable half-life to allow for bid or food admix dosing.

Physicochemical Properties

M.Wt 475.428
Formula C22H20F3N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(trifluoromethoxy)benzyl (3aS,6aS)-5-(1H-benzo[d][1,2,3]triazole-5-carbonyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

References

1. Daniel Hunziker, et al. Front Pharmacol. 2022 Jan 18;12:699535.

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